Also, processes implicated in DNA damage response and DNA mismatch repair were dysregulated in vEDS, as indicated by low mRNA levels of a number of associated genes, such as MSH2, MSH6, RFC1, RFC2, RFC4, SSBP1, ARMT1, CLSPN, RAD21, FANCI, INTS7, NSMCE2, MGME1, FANCB. The gene discussed is RFC4; the disease is Ehlers-Danlos syndrome, vascular type.