Administration of OCA in a model of cirrhosis induced by bile duct ligation (BDL) induced an increase in DDAH-1 protein [48] and an increase in serum ADMA [11], while in the present study regular biliary clearance allows ADMA to be eliminated and OCA did not alter DDAH-1 expression or activity during I/R. Here, DDAH1 is linked to Cirrhosis.