Selective activation of hippocampal CRH neurons by Gq did not alter locomotor activity (3379 ± 220 basic movements) or anxiety-like behavior in the open field (10.9 ± 3.0% time in center) compared to vehicle-injected controls (3095 ± 25 basic movements; 9.3 ± 3.1% time in center). This evidence concerns the gene CRH and Anxiety.