[11] Studies in patients with rheumatoid arthritis using tocilizumab to block IL-6 signaling through the IL-6 receptor have shown beneficial effects, though resulted in side-effects including pro-atherogenic dyslipidemia and increased low density lipoprotein (LDL), [13] which is associated with increased risk of coronary artery disease. Here, IL6 is linked to coronary artery disorder.