GAD2 and type 1 diabetes mellitus: The same study showed that high-glucose stimulation increased the expression of miRNAs associated to autoantigen regulation, and it has been hypothesized that this and other related miRNAs may play a role in maintaining balanced levels of major T1D autoantigens when glucose levels are altered, since the levels of autoantigens like IA2, IA2β and GAD65 also are known to increase in response to high glucose [27–29].