IL-1β mediates the IL-6 signaling pathway [57], and canakinumab, a fully human monoclonal antibody targeting IL-1β, leads to a marked reduction of both, plasma levels of IL-6 and CRP, without lowering the level of low-density lipoprotein (LDL) in patients with diabetes who were at high vascular risk [57]. The gene discussed is IL1B; the disease is diabetes mellitus.