Currently, our group is conducting a phase III randomized controlled trial (RCT) in patients suffering from PAD without options for revascularization: Growth Hormone Angiogenic Study (GHAS), Eudract 2012-002228-34, approved by the Spanish Agency of Drugs and Health Products (AEMPs), and the Autonomic Committee on Research Ethics in Galicia (CAEIG, 2012/378), Spain, in which patients receive GH or placebo. Here, GH1 is linked to peripheral arterial disease.