However, plasma levels of GH must be within normal ranges, since, as it occurs in acromegaly, transgenic mice overexpressing bovine GH develop an endothelial dysfunction, which depends on the age of the animal and the type of blood vessel, indicating that the affectation in endothelial function is most likely produced by increased production of mitochondrial ROS, followed by many other affectations in vascular function [127]. Here, GH1 is linked to acromegaly.