Curiously, similar results to these shown in transgenic mice overexpressing GH, have been reported in hypopituitary Ames dwarf mice aortas in terms of enhanced production of ROS and lesser expression of antioxidant enzymes (for instance, glutathione peroxidase and eNOS), therefore leading to vascular oxidative stress [128], a first step, as stated above, to develop endothelial dysfunction. This evidence concerns the gene GH1 and endothelial dysfunction.