There are two core pathological changes found in the brains of AD patients: the extracellular amyloid plaques formed by the aggregation and deposition of amyloid β-peptide (Aβ) [3,4], and the neurofibrillary tangles—the aggregates of the microtubule-associated protein Tau that is abnormally hyperphosphorylated and accumulates inside neuronal cells [5,6]. Here, MAPT is linked to Alzheimer disease.