Interestingly, the anti-apoptotic inhibitors of apoptosis proteins (IAPs) have also been recognized to function independently of apoptosis-resistance as E3 ubiquitin ligases and regulators of NF-κB signaling, upregulating MMP-9 and EMT-related transcription factors and promoting tumor migration, invasion, and metastasis [14,36,37]. The gene discussed is NFKB1; the disease is neoplasm.