Apoptosis is typically dysregulated in human cancers by pro-survival factors, e.g., nuclear factor-κB (NF-κB), and AKT, and by pro-apoptosis components, e.g., Fas ligand (FASL) and p53-upregulated modulator of apoptosis (PUMA) [10,14]. The gene discussed is NFKB1; the disease is cancer.