Since IL-2, TNF, and IFNγ are nevertheless necessary for an anti-tumor response, the use of Dabra + Tram might form a good balance between preventing an exaggerated cytokine release causing CRS on the one hand and a minimum secretion of the cytokines seen in the setting with Vem + Cobi on the other hand. The gene discussed is IFNG; the disease is congenital rubella syndrome.