The first observations of a double mutation in the BRCA1 and BRCA2 genes was found in 1997 in a casistica of patients of Ashkenazi origin affected by breast and ovarian cancer carrying both the 185delAG in the BRCA1 and the 6174delT BRCA2 gene mutations [5,6]. The gene discussed is BRCA2; the disease is ovarian carcinoma.