In particular, in a study of 95 families carrying the mutation, Higgs et al., showed that the previously reported associations with increased cancer risk are in many cases due to the concomitant presence of a pathogenic frameshift BRCA2 mutation c.6275_6276delTT (Leu2092ProfsTer7) as well as to the non-pathogenic BRCA2 c.9257-16T>C (IVS24-17T>C) that are often found in linkage disequilibrium with p.Lys3326* [16]. Here, BRCA2 is linked to cancer.