BRCA1 and ovarian cancer: Finally, in a study of 48 women with ovarian cancer and high risk of genetic inheritance but negative for both BRCA1 and BRCA2 mutations, Stafford et al., observed two patients carrying the K3326X variant, one with a concomitant RAD51D nonsense mutation and the other with an ATM frameshift mutation, having both developed breast and ovarian cancer [15].