She had three children: a 53-year-old son (III.4), who had received a diagnosis of cutaneous melanoma two years before, but with no mutations; a 51-year-old daughter (III.5) carrying no mutations; and an asymptomatic 48-year-old daughter (III.6) positive to the mutation of the BRCA1 gene. This evidence concerns the gene BRCA1 and cutaneous melanoma.