To unravel the STAT3 signaling network in T-cell lymphomas and to discover key players that may represent feasible targets for ALCL therapies, we designed a time course gene expression profiling experiment (GEP) using two clones (2X and 21) of the ALK positive ALCL cell line (TS-SUP-M2 S3S) which express a doxycycline-inducible STAT3 short hairpin RNA (shRNA) [27,30]. Here, ALK is linked to anaplastic large cell lymphoma.