To validate the role of c-Myc in AOM/DSS-mediated tumorigenesis in Usp9xΔG mice, we inactivated one c-Myc allele in Usp9xΔG mice and compared the number of tumors in c-MycΔG/+Usp9xΔG mice with those in Usp9xΔG mice. The gene discussed is MYC; the disease is infectious otitis media.