The tumor suppressor FBW7 functions as the substrate recognition component of an SKP1, CUL1, and F-box protein–type (SCF-type) E3-ubiquitin ligase complex (12) targeting several oncoproteins, including c-MYC, NICD1 (Notch1 intracellular domain), and c-JUN, for degradation (13–22). The gene discussed is KITLG; the disease is neoplasm.