Sickle cell anemia (MIM#603903) is an inherited hemoglobinopathy, caused by ahomozygous nucleotide substitution (c.20A>T) in the β-globin gene(HBB) that changes a glutamic acid to a valine in the protein.It is an inherited hemoglobinopathy, such as β-thalassemia, and leads to amultisystem disorder characterized by abnormal erythrocytes damaged by the HbShemoglobin, an adult hemoglobin (HbA) variant (Pielet al., 2017). Here, HBB is linked to hemoglobinopathy.