The two components shared 62% of gains and losses, and 72.7% of SNVs (Figure 2; supplementary material, Tables S3 and S4), with shared SNVs affecting the cancer driver genes TP53 [p.Tyr220Cys, moderate effect (SNPeff), common mutation with 354 reported in COSMIC], ESR1 (p.Ser154Leu, moderate effect, none recorded in COSMIC), and TBX3 (p.Glu402_Pro403insGluGlu moderate effect, none recorded in COSMIC). This evidence concerns the gene ESR1 and cancer.