Additionally, various companies managed to develop procedures to modify MN for use in genome editing to induce targeted recombination and correction of the RAG1 gene related to severe combined immunodeficiency (SCID) (Grizot et al. 2009) or XPC gene associated with xeroderma pigmentosum in skin cells (Arnould et al. 2007). This evidence concerns the gene RAG1 and severe combined immunodeficiency.