For example, the reduction of brain-derived neurotrophic factor (BDNF) serum levels has been identified as a memory and cognitive deficit as well as a predictor of the risk of morbidity and mortality in the elderly [17] whereas insulin-like growth type 1 (IGF-1) and vascular endothelial growth factor (VEGF) exhibit direct correlation to the reduction of muscle mass and strength in this population [18,19]. The gene discussed is BDNF; the disease is Cognitive impairment.