ABCB1 and cancer: In the human hepatic cancer Bel-7402 and Bel-7402/FU cells, AST-II downregulated the expression of mdr1 gene and P-glycoprotein, suppressed autophagy by interfering with Beclin-1 and LC3 via MAPK-mTOR pathway, through which it sensitized human cancer resistant cells to 5-FU-induced cell death [77,78].