CDK4 and neoplasm: In addition, APS inhibit the tumor cell growth in Kunming mice with Ehrlich's ascites carcinoma, decrease Bcl-2 and CDK4 levels, increase the percentage of CD3+ and CD4+ T-lymphocytes, the ratio of CD4+/CD8+ T cells and the expression of IL-2/IL-2R in spleen and Bax in tumor tissue [189].