In human NSCLC cell line H460 and tumor tissue from patients with NSCLC, APS inhibited the proliferation and promoted cell apoptosis in a dose and time-dependent manner through suppressing the expression of notch1 and notch3, up-regulating the expression of p53, p21, p16, Bax and caspase-8 [192]. This evidence concerns the gene NOTCH3 and non-small cell lung carcinoma.