Besides its pro-apoptotic and anti-proliferative activities, AMS can modulate the invasiveness and angiogenesis of tumor cells, by down-regulating the VEGF and metastatic proteins metalloproteinase (MMP)-2 and MMP-9, which suggested that AMS may be used for the treatment of advanced and metastatic cancers [58]. The gene discussed is MMP9; the disease is neoplasm.