A study of Weng et al. (2013) revealed that denbinobin induces human glioblastoma multiforme (GBM) cell apoptosis through IκB kinase inactivation, followed by Akt and forkhead in rhabdomyosarcoma dephos-phorylation and caspase-3 activation signaling cascade. Here, CASP3 is linked to glioblastoma.