Acteoside, acquired from the aqueous ethanol extract of the roots of Cistanche tubulosa, was involved in regulating the hypocholesterolemic activity through enhancing the mRNA expressions of apolipoprotein B, very low-density lipoprotein (VLDL) receptor, and cytochrome P450 SCC in HepG2 hepatocytes of hypercholesterolemia mice [25]. The gene discussed is APOB; the disease is Hypercholesterolemia.