Moreover, Rd has been shown to inhibit hepatocellular carcinoma HepG2 cell metastasis via inactivation of MAPK signaling and induction of focal adhesion formation [88], and attenuate breast cancer metastasis in mouse mammary carcinoma 4T1 cells in part through depressing miR-18a-mediated Smad2 expression regulation [89]. Here, SMAD2 is linked to breast carcinoma.