Its overexpression has also been recently reported in acute adult T-cell leukemia/lymphoma.To examine possible downstream effects of the <i>ASCL1</i> upregulation in CLL, we compared the gene expression of sorted CD5<sup>+</sup> cells of the translocation patient to that of CD19<sup>+</sup> B-cells from seven healthy donors and detected 176 significantly deregulated genes (Fold Change ≥2, FDR <i>p</i> ≤ 0.01). Here, ASCL1 is linked to B-cell chronic lymphocytic leukemia.