INSM1 and neuroendocrine neoplasm: <i>INSM1</i>, a well-established ASCL1 target in the nervous system and SCLC, was the gene with the strongest upregulation (Fold Change = 209.4, FDR <i>p</i> = 1.37E-4).<i>INSM1</i> encodes for a transcriptional repressor with extranuclear functions, implicated in neuroendocrine differentiation and overexpressed in the majority of neuroendocrine tumors.