ACE and hydrops fetalis: In patients with HF with reduced ejection fraction (HFrEF), LCZ696 has more effectively reduced all-cause, cardiovascular and sudden death, prevented HF progression and hospitalization, and improved life quality and renal function than enalapril in Prospective comparison of ARNI with ACE inhibitor to Determine Impact on Global Mortality and morbidity in Heart Failure (PARADIGM-HF) trial [260–263].