MUC16 and breast cancer: The most complete proteomics study was performed by Shaheed et al. [121], identifying more than 1900 unique gene products including mitogenic growth factors (IGF1, IGF2, EGF, PDGFC, PGGFD, TGFβ1, VEGFA), cell adhesion proteins (CEACAMs, NCAM2, ICAM1), established breast cancer biomarkers (EGFR, mucin-1/CA 15-3, mucin-16/CA-125, MUCL1, cytokeratins 5, 8, 14 and 18) as well as 46 candidate biomarkers under investigation by the National Cancer Institute Early Detection Research Network [122].