To determine the extent of unspecific uptake of anti-B220 MSNs, B220 negative murine AML LSCs, derived from a murine AML model driven by the overexpression of the proto-oncogene Cdx2, were incubated with the anti-B220 MSNs for 24 hours before analysis on the fluorescence microscope. This evidence concerns the gene CDX2 and acute myeloid leukemia.