To target the particles specifically to B220 positive murine AML LSCs in the CALM-AF10 model, a IgG2α, kappa monoclonal anti-B220 which reacts with the exon A-restricted isoform of the mouse CD45R was covalently conjugated to remaining amino groups on the MSNs through EDC/NHS-coupling. This evidence concerns the gene PTPRC and acute myeloid leukemia.