TP53 and colorectal carcinoma: Interestingly, these missense mutations belong to two p53 mutations sub-groups that define p53 mutation type according to their impact on the DBD folding; “DNA-contact mutations” (R248, R273), and the “p53 conformational mutations” (R175) [14], Indeed, it is well-accepted that mutant p53 plays an important role in CRC development [3].