BCL2 and breast cancer: Since previous studies show that anti-apoptotic Bcl-2 family members Bcl-2 and Bcl-xL promote cell survival in tamoxifen-treated breast cancers13, we measured expression of Bcl-2 and Bcl-xL in parental and LTED-selected breast cancer cells, finding similar levels of Bcl-2 and Bcl-xL in LTED-selected HCC1428 and T47D cells as compared to their parental counterpoints cultured in estrogen-replete media (Fig. 1c).