Consequently, statistical analysis of heteroplasmies clearly support the notion that the parameters of chronic liver injury (i.e., METAVIR, PT-INR, APRI, AST, and ALT) positively correleated with the extent of hepatic failure due to critical mutations in mtDNA protein-coding genes (i.e., ND2 and ND4) in BA patients (i.e., 8, 9, 12, 14, 16, 17, and 19) when compared to CC patients. This evidence concerns the gene GPT and liver failure.