Consequently, statistical analysis of heteroplasmies clearly support the notion that the parameters of chronic liver injury (i.e., METAVIR, PT-INR, APRI, AST, and ALT) positively correleated with the extent of hepatic failure due to critical mutations in mtDNA protein-coding genes (i.e., ND2 and ND4) in BA patients (i.e., 8, 9, 12, 14, 16, 17, and 19) when compared to CC patients. This evidence concerns the gene MT-ND4 and liver failure.