IL6 and neoplasm: For sarcomas, 3/6 Δ122/Δ122 IL-6+/+ mice showed metastases to the gut, liver, spleen, pancreas or lymph node; 1/3 of Δ122/Δ122 IL-6+/− mice had a single metastasis to the heart; and 0/4 Δ122/Δ122 IL-6−/− mice had metastases, although this did not quite reach statistical significance (p = 0.09, χ2-test; Table 2) due to low numbers of tumours.