Because in our first approach of FoxM1 overexpression for restoration of cell arrest or necrosis, the overexpressed FoxM1 protein level was never restored in the presence of miR-SX4, we utilized the second approach using cervical cancer cell line, HeLa, where FoxM1 was overexpressed first, followed by miR-SX4 transfection so that FoxM1 is already overexpressed in these cells before miR-SX4 is introduced which could also overcome the extremely high rate of cellular death induced by miR-SX4. The gene discussed is FOXM1; the disease is cervical cancer.