The FoxM1 downregulation by the siRNA induced necrosis by approximately 1.8-fold in HeLa; 1.6-fold in CaSki and 1.9-fold in SiHa (Fig. 5c), while miR-SX4 transfection induced it by 4~16 fold, suggesting that miR-SX4 has more potent anti-cervical cancer property than si-FoxM1 alone. This evidence concerns the gene FOXM1 and cervical cancer.