SIGLEC1 and tuberculosis: Amongst the top 10 DE genes upregulated in M. bovis AF2122/97 infected animals (or conversely, downregulated in M. tuberculosis H37Rv animals) included those encoding: the macrophage restricted cell surface receptor SIGLEC1 that is known to be involved in pathogen uptake, antigen presentation and lymphocyte proliferation54; the CD4-coreceptor and fractalkine receptor CX3CR1, which has been linked to tuberculosis susceptibility and the impairment of macrophage and dendritic cell migration55,56; and Interferon-Regulated Resistance GTP-Binding Protein (MX1) at day 14 (Fig. 4B).