The result showed that DOT1L-targeted inhibition inhibited H3K79 methylation in all cell lines and specifically inhibited cell growth in leukemia cells with MLL translocations such as MV411, but not in melanoma cells, or leukemia without MLL translocations, such as HL-60 (Supplementary Fig. 2e). The gene discussed is KMT2A; the disease is leukemia.