The SLE-associated risk A allele disrupts the binding of NF-κB transcription factors and significantly reduces the expression of TNFAIP3. In our previously reported study, we also showed that TALEN-mediated TT>A enhancer knockout leads to reduced expression levels of TNFAIP3 and significant increases in NF-κB signaling activity (26). Here, NFKB1 is linked to systemic lupus erythematosus.