IRS2 and cancer: miR-7 can down-regulate some factors associated with cancer signaling pathways, such as epidermal growth factor receptor (EGFR), insulin-receptor substrate-1 (IRS-1), insulin-receptor substrate-2 (IRS-2), rapidly accelerated fibrosarcoma 1 (Raf1), p21-activated kinase 1 (Pak1), activated cdc42 kinase 1 (Ack1), insulinlike growth factor-1 receptor (IGF1R), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta (PIK3CD), and mammalian target of rapamycin (mTOR) [48].