The areas under curves (AUCs) for age, serum CEA level, tumor size, GGO type and bubble-like sign were 0.59, 0.62, 0.87, 0.72, and 0.58 (p: 0.0058, 0.0002, < 0.0001, < 0.0001, and 0.001, respectively), with sensitivities of 57%, 54%, 86%, 71%, 35% and specificities of 59%, 65%, 72%, 73%, 83%. The gene discussed is CEACAM5; the disease is neoplasm.