P-MAPA immunotherapy resulted in high p65 expression (Fig. 6d I and II; the level of fluorescence increased from 43% ± 0.67 (OC) to 86% ± 11.3 (P-MAPA) as well as CIS therapy (Fig. 6d I and III; the level of fluorescence increased from 43% ± 0.67 (OC) to 102% ± 14.1 (CIS). Here, LRRC25 is linked to in situ carcinoma.