Notably, P-MAPA therapy positively regulated TLR4 in these cells (1.50-fold increase vs. OC; Table 1, Fig. 5e, f, i, k), and CIS treatment also upregulated TLR4 but not in the same intensity as P-MAPA did (1.37-fold increase vs. OC; Table 1, Fig. 5e, g, i, k). The gene discussed is LRRC25; the disease is in situ carcinoma.