Regarding different OC cell lines (OVCAR3, SKOV3, A2780), the TLR4 activation induced IL-1 receptor-associated kinase (IRAK)-4 and NF-kB signaling, and c-Jun, IL-6 and IL-8 production, all of which related to tumor chemoresistance [5]. The gene discussed is IRAK4; the disease is neoplasm.