Herein, our data demonstrate that INPP4B functions to promote leukemia cell survival in a SGK3-dependent manner, high levels of INPP4B are at least partially caused by the NPM1 mutant via ERK/Ets-1 signaling, and high INPP4B is potentially correlated with poor clinical outcome in NPM1-mutated leukemia (Fig. 7f). This evidence concerns the gene SGK3 and leukemia.