Consistent with these findings, we examined the mRNA levels of INPP4B by qRT-PCR from 36 primary AML blasts and found that INPP4B was more highly expressed in NPM1-mutated AML (n = 14), as compared to NPM1-unmutated AML (n = 22) cases (p = 0.0246, Fig. 1b). This evidence concerns the gene NPM1 and acute myeloid leukemia.