The percentage of patients with NO problems decreased in three of the dimensions (self-care, pain/discomfort, and anxiety/depression) in group A, whereas the percentage of patients with NO problems increased in four of the dimensions (mobility, self-care, usual activity and pain/discomfort) in group B. The percentage of patients receiving IFN-free therapy (group B) who reported anxiety/depression remained unchanged, whereas the percentage of patients reporting anxiety/depression more than doubled in group A. This evidence concerns the gene IFNA1 and major depressive disorder.