Moreover, it has been reported that the introduction of the miR-124 precursor into BMMs dramatically reduced RANKL-dependent osteoclast differentiation, whereas an miR-124 inhibitor potently enhanced osteoclastogenesis [36], indicating the crucial role of miR-124 in bone homeostasis, but it is unknown whether tumor cell-derived miR-124 contributes to the interaction between tumor cells and the bone microenvironment. This evidence concerns the gene TNFSF11 and neoplasm.