These observations further support that the cooperation between HOX/FGF2/β-catenin/CDX4, HOX/αVβ3/Syk and αVβ3/PI3K/Akt/GSK3-β/β-catenin is important for leukemogenesis and probably also chemosensitivity in human AML. The gene discussed is CDX4; the disease is acute myeloid leukemia.