Thus, the Wnt-β-catenin pathway seems important for various subsets of AML and not only patients with MLL-translocations, and the possible role of ITGB3 suggested by the observations in this murine AML models may therefore be relevant also for several other AML subsets and not only this specific MLL-variant. The gene discussed is KMT2A; the disease is acute myeloid leukemia.