SPP1 and acute myeloid leukemia: The authors also presented experimental evidence for a role of αVβ3 in osteopontin-induced chemoresistance in FLT3-ITD AML, and this seemed to be caused by activation of the αVβ3/PI3K/Akt/glycogen synthase kinase-3 β (GSK3-β)/β-catenin pathway.