CTNNB1 and leukemia: This leukemia variant depends on Wnt-β-catenin; the negative β-catenin regulator Apc is decreased [49] and at the same time this leukemia is also characterized by high expression of ITGB3 as well as β-catenin (Ctnnb1) and High mobility group box 3 (Hmgb3) [50].