These observations further support that the cooperation between HOX/FGF2/β-catenin/CDX4, HOX/αVβ3/Syk and αVβ3/PI3K/Akt/GSK3-β/β-catenin is important for leukemogenesis and probably also chemosensitivity in human AML. This evidence concerns the gene AKT1 and acute myeloid leukemia.