Since rs10951982 is the most significant variant in our current study, and in lieu of its function in immune diseases as well as a potential role in NOX1-induced oxidative stress, our discovery might not only suggest an inflammatory microenvironment created by RAC1 that is in favor of melanoma progression [62], but also indicate an elevation of ROS level via RAC1 in melanoma etiology. Here, RAC1 is linked to immune system disorder.