In contrast, homozygous minor allele genotypes at both rs8031 (SOD2) and rs2536512 (SOD3) exhibited significant association with a reduced risk of melanoma in the additive allele model, with 84% reduction in odds of melanoma (OR 0.16, 95% CI: 0.06, 0.39, p < 0.001) for rs8031 (SOD2), and 92% reduction in odds of melanoma (OR 0.08, 95% CI: 0.01, 0.31, p = 0.001) for rs2536512 (SOD3). This evidence concerns the gene SOD2 and melanoma.