The homozygous minor allele TT genotype in rs8031 (SOD2) was found associated with a decreased risk of melanoma, with an OR of 0.32 (95% CI: 0.09, 0.94, p = 0.047) in the additive model, and an OR of 0.26 (95% CI: 0.08, 0.70, p = 0.011) in the recessive allele model, which indicated that homozygous minor alleles TT reduced the odds of melanoma by 74%, but neither of these results reached the universal significance level of 0.00238. This evidence concerns the gene SOD2 and melanoma.