Use of the FGFR1 inhibitor, PD-166866, was particularly promising as it not only hindered in vitro MPM cell proliferation and caused an increase in death via apoptosis, but also reduced in vivo MPM tumor growth in mouse models; this was accompanied by synergism when coupled with cisplatin or radiotherapy treatment [50]. The gene discussed is FGFR1; the disease is neoplasm.