Cornelissen et al. demonstrated that factors secreted by the tumor cells transformed normal macrophages into malignant M2 macrophages, which reciprocally produce cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-10 (IL-10), VEGF, and transforming growth factor beta (TGF-β), which contribute to tumor formation and development [82]. The gene discussed is TGFB1; the disease is neoplasm.