This symbiosis between tumor cells and their stromal neighbors has been demonstrated by co-culturing lung fibroblasts with mesothelioma cell lines or patient-derived fibroblasts, because proliferation and migration of cancerous cells increased significantly due to activated MET-induced HGF; these effects were abrogated when the cells were treated with an anti-HGF antibody or FGFR/PDGFR inhibitors [70]. This evidence concerns the gene PDGFRB and neoplasm.