When exposed to asbestos, mice with mono-allelic deletions of P16INK4a or P19ARF (human: P14ARF) developed mesothelioma earlier and more often than their wild type littermates, and those with deletions of both P16INK4a and P19ARF showed even faster progression into malignancy relative to the mice bearing single deletions [57]. The gene discussed is CDKN2A; the disease is mesothelioma.