CFL2 and gastric cancer: These data established the connection among S100A4, miR-3189-3p, and CFL2 in GC cells, demonstrating that miR-3189-3p mimics enhanced the effects of S100A4 siRNA on the inhibition of the proliferation and migration of MGC803 GC cells by targeting CFL2. Overall, our findings suggested that in order to obtain an ideal effect when using S100A4 as a target to treat gastric cancer, attention should be paid to the counteract factors.