To investigate the underlying mechanism by which S100A4 affects the properties of GC cells, we analyzed the differentially expressed gene profile using a cDNA microarray after S100A4 suppression in GC cell line MGC803, and found that GDF15 was significantly downregulated among the 173 differentially expressed genes, and could mediate the effect of S100A4 on the properties of GC cells [10]. The gene discussed is GDF15; the disease is gastric cancer.