After S100A4 knockdown in cancer cells, certain genes that inhibit proliferation and migration (e.g., FAM107B and E-cadherin) were upregulated [27,30], while those genes that normally promote proliferation and migration (e.g., NF-κB, p65 and MMP2) were downregulated [7,31]. This evidence concerns the gene NFKB1 and cancer.