Median (range) sex hormone-binding globulin levels (nmol/L) in patients with PCOS, CAH, ACC, and OHT were 37.7 (11 to 212.2), 44.5 (21 to 131.1), 64.2 (28.8 to 270), and 60.3 (38.8 to 218.3), respectively; the corresponding free androgen indexes were determined as 4.5 (0.3 to 49.6), 8.7 (1.4 to 117.9), 8.4 (0.6 to 39.2), and 10.6 (4.4 to 28.4), respectively. The gene discussed is SHBG; the disease is adrenal cortex carcinoma.