Median (range) sex hormone-binding globulin levels (nmol/L) in patients with PCOS, CAH, ACC, and OHT were 37.7 (11 to 212.2), 44.5 (21 to 131.1), 64.2 (28.8 to 270), and 60.3 (38.8 to 218.3), respectively; the corresponding free androgen indexes were determined as 4.5 (0.3 to 49.6), 8.7 (1.4 to 117.9), 8.4 (0.6 to 39.2), and 10.6 (4.4 to 28.4), respectively. This evidence concerns the gene SHBG and congenital adrenal hyperplasia.