Furthermore, among patients with diabetic nephropathy, baseline albuminuria was a strong independent predictor of progression to ESKD in the Reduction in End Points in Noninsulin-Dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan (RENAAL) study and the Irbesartan in Diabetic Nephropathy Trial (IDNT) [13, 14]. This evidence concerns the gene AGT and type 2 diabetes mellitus.