In the German Chronic Kidney Disease cohort, which included 5,217 patients with a mean eGFR of 47.1 ml/min/1.73m2, 41.8% patients had eGFR < 60 ml/min/1.73m2 and urinary albumin/creatinine ratio (ACR) < 30 mg/g [16]. The gene discussed is ALB; the disease is chronic kidney disease.