In the downregulated network, containing 88 nodes and 350 edges, nine genes, namely breast cancer 1, early onset (BRCA1), retinoblastoma-like 1 (p107) (RBL1), toll-like receptor 4 (TLR4), CD19, HEAT repeat-containing 1 (CD19), Fanconi anemia complementation group D2 (FANCD2), proteasome subunit beta 11 (PSMB11), biliverdin reductase A (BLVRA), and GINS complex subunit 4 (GINS4), showed higher PPI degrees and betweenness values (Fig 2B, Table 2). The gene discussed is HEATR1; the disease is cancer.