It is known that the mitogen-activated protein kinases (MAPKs) family including ERK and p38 MAPK and phospatidylinositol-3-kinase (PI3K)/Akt activation are necessary and sufficient to promote angiogenesis [7,36,37], whereas the inhibition of these pathways might result in successful anti-angiogenic and anti-tumor effects [38,39,40]. This evidence concerns the gene WNK2 and neoplasm.