Geou-Yarh Liou et al., demonstrated, using in vitro and in vivo models of pancreatic adenocarcinoma, that K-RasG12D induced mitochondrial flux produces high levels of reactive oxygen species (ROS) that subsequently increase the activity of NF-κB1 and NF-κB2, leading to up regulation of epidermal growth factor receptor (EGFR) signaling [11]. Here, EGFR is linked to pancreatic adenocarcinoma.