Anti-TNF strategies are attractive alternatives for the treatment of SJS/TEN.Thalidomide, a potent inhibitor of TNF-alpha, was tested in a clinical trialthat was prematurely terminated by increased mortality in the treatmentgroup.(46) Infliximaband etanercept have shown benefits in a small number of cases in uncontrolledstudies. Here, TNF is linked to Schwartz-Jampel syndrome.