The case-control multilocus analysis of the association of the polymorphicvariants of PSCK9 (rs562556), APOE (epsilonpolymorphism, rs7412 and rs429358), LPL (rs320), MTHFR(rs1801133), eNOS (rs2070744), and the 9p21 region(rs1333049) with the risk of MI revealed the PSCK9,APOE, LPL, and eNOS alleles/genotypessignificantly associated with MI and the bi- and triallelic combinations thatcarried the MTHFR and the 9p21 region alleles/genotypes alongwith the variants of the aforelisted genes. This evidence concerns the gene NOS3 and myocardial infarction.