Each of the examined lipid metabolism genes (PCSK9,LPL, and APOE) turns out to be associatedwith the risk of MI; the OR of the risk genotypes ranges from 1.45 to 1.96 butthe significance level is rather low (p = 0.013–0.032).The involvement of the lipid metabo lism genes in the development of MI showsgood agreement with the well-known fact that disorders of lipid metabolism,high cholesterol level and elevated atherogenic index lead to formation ofatheromatous plaques in the arterial tunica intima. The gene discussed is APOE; the disease is metabolic process.