PCSK9 and metabolic syndrome: The PCSK9 protein (proprotein convertase subtilisin/kexin type 9) encoded by the PCSK9 gene partakes indegradation of low-density lipoprotein receptors and is used as a target intreatment of dyslipidemia and related CVDs[7].The APOE gene product, apolipoprotein E, is involved in lipidtransport and plays a crucial role in the development ofCVD [8].