Indeed, ARE linked to a nonselective minimalpromoter was previously shown to provide tumor-specific expression owing to anaberrantly activated Nrf2 transcription factor[14-19]or intrinsically higher ROS levels in tumor cells[11, 12].As we demonstrated, a hybridpromoter containing the human TERT gene promoter and AREderived from the human GCLM gene promoter showed betterperformance in 3 of 4 tested cancer cell lines both in reporter gene assay andin the CD : UPRT-5FC suicidal cancer gene therapy scheme. Here, TERT is linked to cancer.